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9 Celebs Who Took Weight Loss Drugs Like Ozempic and How it Worked For Them

From Oprah to Jim Gaffigan, these stars shared their experiences with weight loss meds.

Hollywood has always put intense pressure on celebrities to stay in shape, and with the rise of weight loss medications like Ozempic and Mounjaro, many stars have turned to these drugs for help. Originally developed to treat diabetes, these medications have become a popular option for those struggling to shed extra pounds. Some have raved about the results, crediting the medication with curbing cravings and making weight management easier. Others had a different experience, seeing little to no change or dealing with unexpected side effects.

Weight loss has always been a hot topic, but these drugs have sparked a bigger conversation about body image, health, and the lengths people go to in order to feel their best. Celebrities have been especially vocal, sharing their successes, frustrations, and everything in between. Some saw major transformations, while others realized these medications weren't the right fit. These nine stars have spoken openly about their experiences, offering a glimpse into what worked, what didn't, and how these drugs have changed the weight loss landscape.

1

​Kandi Buruss


Kandi Buruss hits the red carpet for The Grammy's

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Singer and Real Housewives of Atlanta star talked about her experience with taking Ozempic with People. "Last year, I tried it," she told the outlet. "I saw so many people who were trying it and losing weight. So I was like, 'Okay, I'm going to try this.' And I didn't lose any weight…My doctor was like, 'I don't know what the problem is, I'm not seeing this in other people.' It didn't curb my appetite. I know some people are like, 'Oh, I can't eat.' Not me! I was eating appetizers, a regular meal and dessert, okay? It didn't stop anything for me." Buruss says that she decided to get off of it and use Hydroxycut, eat better, and workout more to lose weight.

2

​Caroline Stanbury


Caroline Sansbury stops by BravoCon

Caroline Stanbury starred on both Ladies of London and The Real Housewives of Dubai. On an episode of her podcast, she talked about her success with Ozempic. "After 40, we all know, it's very, very hard to lose weight. But I met so many 40-year-old women going, 'How have you done it?' And I don't want to lie to you … I used Ozempic, which I think is one of the best tools if you're able to use it. What did Kate Moss say? 'Nothing tastes as good as skinny feels.' There's something to be said for that."

3

Harvey Fierstein​

Harvey Fierstein is looking better than ever at The 77th Tony Awards

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Harvey Fierstein is a successful actor and playwright, best known for his role in Hairspray. Fierstein revealed to Page Six that his weight loss secret is using Zepbound. "I've been skinny before, that's the sad part," he said. "I've been skinny, I've been fat, I've been skinny, I've been fat. What's different is what the drug actually does for you which is I don't feel like I'm dieting. I feel like a normal person. I can go and have dinner with friends and not have to eat every piece of bread on the table and then not go have ice cream when I've done with dinner."

4

Fat Joe​

A thinner Fat Joe performs during Juicy Fest in Perth, Australia

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Fat Joe is a rapper and a member of the Terror Squad. He is best known for the song, "Lean Back." Joe has diabetes, and takes Ozempic to manage it and his weight. He tells Us Weekly that the medication has forced him to change his diet. "We just try to eat everything with the least carbs as possible," Joe said. "So we try to stay away from the bread, the pasta, the rice. That's the smartest way to eat. Ozempic says you may only have two pieces of your favorite stuff."

5

​Jim Gaffigan

Jim Gaffigan attends Hulu's "Hularious" Stand-Up Comedy Celebration at The Stand

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Stand up comedian, Jim Gaffigan, recently lost a lot of weight. He turned to the weight-loss drug Mounjaro at the advice of his doctor. Gaffigan told People, "She was like, 'Well, some people are against it.' And I'm like, 'I don't care, I'll try it.' My knees hurt and my cholesterol was kind of not great. And that's some of why I wanted to talk about it, because I almost thought it was kind of odd that people were resistant to talking about it. I don't think there's anything wrong with it. There's people walking around that obviously do not have blonde hair — yet they do. I don't think that's weird, either. It's just whatever gets you through."

6

​Dolores Catania

A svelte Delores Catania poses at the 2024 MTV Video Music Awards

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Dolores Catania is a cast member on The Real Housewives of New Jersey and is currently appearing on The Traitors. In an interview on Sherri Shepherd's talk show, Catania and her RHONJ co-star, Margaret Josephs revealed they both take Ozempic for weight loss. "I don't know why because there's no shame in it," Catania said. "If a doctor gives it to you, if you're doing things right, you're becoming healthier by losing weight. It's a bunch of great things that come along with this."

7

​Margaret Josephs

Margaret Josephs attends Summer Hamptons Evening (S.H.E.) 2024

Jared Siskin/Patrick McMullan

Margaret Josephs is a cast member on The Real Housewives of New Jersey. She also talked about her decision to take Ozempic on Sherri. "After menopause, it's so hard to lose weight," Josephs said. "And then you're shamed for it if you're heavy. It shuts off that food noise, my blood work is great. [Before Ozempic] I couldn't do anything. It doesn't matter if I was eating right or exercising so I don't know why there's any shame in it if it's helpful to people."

8

Tori Spelling​

Can't touch this! Tori Spelling channels her inner MC Hammer at an iHeart RADIO event

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Tori Spelling is an extremely successful actress. She is known for roles on Beverly Hills, 90210 and Saved By The Bell. On an episode of her podcast, misSPELLING, she revealed that her doctor recommended that she take Mounjaro to lose weight after having her fifth child. "She put me simultaneously with the hormones on Mounjaro," she said. "I'm no longer on it, but I did lose weight and I haven't been on it since the end of January."

9

​Oprah Winfrey

Oprah Winfrey at the Brunello Cucinelli Dinner at Chateau Marmont

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Oprah Winfrey has been open with her weight loss journey. She revealed to People that her doctor recommended she take a medication to help with it. "The fact that there's a medically approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for. I'm absolutely done with the shaming from other people and particularly myself."

Anna Bechtel
Anna Bechtel is a freelance writer currently based in Hamden, CT. Read more
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