10 Celebs Who Have Lost Weight With Help of GLP-1 Injections
In recent years, GLP-1 injections— like Ozempic, Mounjaro, Wegovy, and more—have been used to help people lose weight. The medications were originally intended to treat diabetes. However, their appetite-suppressing nature has also helped individuals manage their overeating habits. Now, millions of Americans, including celebrities, are on some form of injectable weight-loss drugs.
Although the side effects can be intense, plenty of stars have lauded the results of taking a GLP-1 amid their wellness journeys. Here are 10 celebrities who have taken weight-loss drugs to slim down.
1. Amy Schumer
Amy Schumer, 43, is another celebrity who has been transparent about her use of a GLP-1 medication for weight loss.
In a March 2025 Instagram video, the Life & Beth star shared that although she tried Wegovy three years ago but stopped because of the side effects, she has since found a weight-loss drug that she tolerates well.
"Mounjaro's been great," the actress revealed. "…I'm having a really good experience with it, and I wanted to keep it real with you about that."
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2. Oprah Winfrey
Oprah Winfrey, 71, opened up about how a GLP-1 medication helped her maintain her weight after years of yo-yo-ing and enduring public jabs from her talk show.
"The fact that there's a medically approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for," she told PEOPLE. "I'm absolutely done with the shaming from other people and particularly myself."
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3. Jim Gaffigan
Comedian Jim Gaffigan, 58, lost 50 pounds while taking Mounjaro.
"I feel good," he told PEOPLE. "I'm just grateful because it's such a better life."
In his comedy special The Skinny, the comedian poked fun at taking the GLP-1 injection.
"These people will come up to me and accuse me of being on an appetite suppressant. They're like, 'You're on Ozempic! Admit it, you're on Ozempic!' And I'm not, all right?" he said. "I'm on a different one. I'm on Mounjaro, which is better, right? 'Cause it sounds like an Italian restaurant."
4. Meghan Trainor
Meghan Trainor, 31, shared about her weight-loss medication journey in a March 2025 Instagram post.
"I've worked with a dietician, made huge lifestyle changes, started exercising with a trainer and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy," she wrote. "And I'm so glad I did because I feel great."
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5. Kelly Clarkson
Kelly Clarkson, 43, shared on her eponymous talk show that taking a GLP-1 injection has been a part of her weight-loss journey.
"Everybody thinks it's Ozempic," she told Whoopi Goldberg on The Kelly Clarkson Show. "It's not. It's something else. But it's something that aids in helping break down the sugar. Obviously, my body doesn't do it right."
6. Whoopi Goldberg
Speaking Whoopi Goldberg, the View co-host, 69, also publicly addressed who taking a GLP-1 medication has helped her.
"I will tell you, I weighed almost 300 pounds when I made Till," Whoopi said on The View, per NBC Connecticut. "I had taken all those steroids, I was on all this stuff, and one of the things that's helped me drop the weight is Mounjaro. That's what I use."
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7. Kathy Bates
Kathy Bates, 76, dropped 100 pounds over a seven-year span with the help of Ozempic. However, she stressed that she lost the first 80 pounds through changes to her diet and exercise before losing an additional 20 pounds on the GLP–1 injection.
"There's been a lot of talk that I just was able to do this because of Ozempic," Kathy told PEOPLE. "But I have to impress upon people out there that this was hard work for me, especially during the pandemic. It's very hard to say you've had enough."
8. Charles Barkley
NBA Hall of Famer Charles Barkley, 62, spoke about taking Mounjaro during the Dan Patrick Show in 2023. While on the drug, he went from 352 pounds to approximately 290 pounds.
"At some point, I've got to get off the drug, but I feel so good physically I've got to make sure I don't get fat again," Charles explained. "You don't even realize how crappy you feel until you start losing weight."
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9. Sharon Osbourne
Sharon Osbourne, 72, opened up about her GLP-1 journey during an interview with the Daily Mail in November 2023.
"I started on Ozempic last December and I've been off it for a while now, but my warning is don't give it to teenagers, it's just too easy," she warned. "You can lose so much weight and it's easy to become addicted to that, which is very dangerous. I couldn't stop losing weight and now I've lost 42lb and I can't afford to lose any more."
10. Sunny Hostin
Sunny Hostin, 56, is another The View co-host who found weight loss success with the help of a GLP-1 medication.
"During COVID, I gained 40 pounds. All I did was eat…I love to cook, and I found out, I love to eat," she detailed. "And I was horrified about the fact that I would have to come out on air. So I also took Mounjaro."
She later stopped the drug, telling the Daily Mail, "I feel really great. I don't know what everyone else's experience with it is, but I never gained any weight back."
